Bacteriostatic Water – Sterile Solution for Medication Reconstitution

Ensuring Sterility and Safety in Injectable Therapies

What Is Bacteriostatic Water?

Bacteriostatic Water is a sterile, nonpyrogenic solution of water for injection containing 0.9% (9 mg/mL) benzyl alcohol as a bacteriostatic preservative. It is designed for diluting or dissolving drugs that require reconstitution before injection. Unlike sterile water, which is intended for single-use only, bacteriostatic water can be used multiple times, making it ideal for medications that are administered in multiple doses over time .

Key Benefits:

• Prevents Bacterial Growth: The benzyl alcohol in bacteriostatic water inhibits bacterial growth, maintaining the sterility of the solution during multiple withdrawals.

• Extends Shelf Life: Allows reconstituted medications to be stored safely for longer periods, reducing waste and improving cost-effectiveness.

• Versatile Use: Suitable for diluting or dissolving injectable medications, including peptides, hormones, and other biologics .

Usage Guidelines:

• Reconstitution: Follow the manufacturer’s instructions for the specific medication being reconstituted. Typically, bacteriostatic water is used to reconstitute peptides, hormones, or other injectable medications in amounts ranging from 0.5mL to 2mL per vial of medication.

• Administration: After reconstitution, administer the medication as directed by a healthcare professional.

• Storage: Store at room temperature (15-30°C or 59-86°F), away from direct sunlight. Do not freeze. Discard 28 days after first use or as directed by the medication instructions .

Safety Considerations:

• Not for Use in Neonates: Bacteriostatic water contains benzyl alcohol, which can cause serious adverse reactions, including “gasping syndrome,” in neonates and low-birth-weight infants. It should not be used in this population unless absolutely necessary .

• Proper Handling: Always use aseptic technique when withdrawing from the vial to prevent contamination.

• Expiration: Discard any unused solution after 28 days of opening to ensure safety and efficacy .